Mouse Mammary Tumor Virus–like Sequences in Human Breast Cancer
نویسندگان
چکیده
Authors' A Sciences, F of Medicin 3Austrianov Forensic S Australia; 5 Area Health 6Douglas H Note: Supp Online (http In this artic human bre malignanci Correspon and Biomo Sydney, N Fax: 61-2-9
منابع مشابه
The relationship between Human Papillomavirus and Epstein-Barr virus infections with breast cancer of Iranian patients
Background: Breast cancer is the malignancy in humans and other mammals. Several risk factors are involved in their appearance such as higher hormone levels and obesity. Identification of a mouse mammary tumor virus supports a viral etiology for breast tumors in animals. Viruses have been implicated in the development of various cancers, but viral induction for formation breast cancer is contro...
متن کاملNo evidence of mammary tumor virus env gene-like sequences among Iranian women with breast cancer.
OBJECTIVE The mouse mammary tumor virus (MMTV) is the well-established etiological agent of mammary tumors in mice. A series of studies have implicated that a human murine mammary tumor virus-like virus occurs in human breast cancer, but it is unclear whether it has any causal role. METHODS The aim of the present study was to investigate the presence of MMTV env gene-like sequences in a group...
متن کاملMouse mammary tumor-like virus is associated with p53 nuclear accumulation and progesterone receptor positivity but not estrogen positivity in human female breast cancer.
PURPOSE The purpose is to compare the presence of proteins with known associations with breast cancer-progesterone receptor (PgR), estrogen receptor, and p53, with the prevalence of mouse mammary tumor virus (MMTV)-like DNA sequences in human female breast cancers. EXPERIMENTAL DESIGN A cohort of 128 Australian female breast cancers were screened for MMTV-like DNA sequences using PCR. The pre...
متن کاملMouse mammary tumor virus-like gene sequences in breast tumors of Australian and Vietnamese women.
PURPOSE There is considerable evidence that the presence of mouse mammary tumor virus (MMTV)-like gene sequences in human breast cancer is highly associated with human breast carcinoma. Previous studies have found MMTV-like gene sequences in 38% of breast cancer tissue from United States women. The prevalence of these sequences in Australian and Vietnamese women has never been reported. EXPER...
متن کاملMouse mammary tumor virus-like RNA transcripts and DNA are found in affected cells of human breast cancer.
Identifiable risk factors for the development of breast cancer include age, diet, family history, and lifetime estrogen exposure. An infectious agent (mouse mammary tumor virus; MMTV) is known to cause murine breast tumors and may be involved in the pathogenesis of human disease. Multiple studies have detected MMTV-like sequences in 30 to 60% of breast cancer samples and up to 1.8% of samples f...
متن کاملMouse mammary tumor virus-like env sequences in human breast cancer.
Mouse mammary tumor virus (MMTV) has long been known as a causal agent of breast cancer in mice. To date, varied MMTV-like envelope gene (env) sequences have been identified in up to 74% of human breast cancers. However, the role and origin of these MMTV-like sequences in human breast cancer remain uncertain. Our study was initiated to study the integration of MMTV-like env sequences in human b...
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